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ST638 is a tyrosine kinase inhibitor [1].

Tyrosine kinases are a family of protein kinases that phosphorylate the serine and threonine on other proteins. Phosphorylation of proteins by kinases has been involved in signal transduction and regulating cellular activity, such as cell division. Tyrosine kinases function in a variety of processes, such as mitogenesis, induction of mitosis, and transmembrane signaling [2].

In human platelets, preincubation with 50 μM of ST638 completely blocked the platelet aggregation induced with 0.05 unit/ml of thrombin. ST638 inhibited the increase of protein-tyrosine phosphorylation bands induced with thrombin in a dose-dependent manner. ST638 blocked the platelet aggregation and protein-tyrosine phosphorylation induced with thrombin in aspirin-treated platelets [1]. In terminal erythroid differentiation of mouse erythroleukemia (MEL) cells, ST638 effectively induced differentiation in a synergistic manner [3]. In rat and rabbit pulmonary artery cells, ST 638 (0.5 to 40 μmol/L) blocked IK in a dose-dependent manner

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