化学性质:
规格 | 10mM (in 1mL DMSO) 10mg 50mg |
CAS | 112529-15-4 |
别名 |
|
化学名 | 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride |
分子式 | C19H20N2O3S.HCl |
分子量 | 392.9 |
溶解度 | ≥ 19.65 mg/mL in DMSO, ≥ 7.52 mg/mL in EtOH with ultrasonic and warming |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Pioglitazone HCl is a potent and highly selective agonist of PPARγ with IC50 value of 3μM[1].
Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue. It is treated for hyperglycemia and Type 2 diabetes (T2D). Pioglitazone needs insulin as a co-factor for PPAR agonism so it is not effect when being treated to late stages of T2D with developed insulinopenia. In clinical trials, 15mg pioglitazone produces significant improvements in HbA1c and fasting plasma glucose (FPG) [2].
Pioglitazone is also reported to have multiple beneficial effects on lipid metabolism. It produces significant decreases in TG and significant increases in high density lipoprotein (HDL) in clinical studies [2].
特别提醒:
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标签:Pioglitazone HCl
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