化学性质:
规格 | 10mM (in 1mL DMSO) 10mg 25mg 50mg 100mg |
CAS | 54 |
别名 | FAAH Inhibitor II, URB-597, URB 597, KDS-4103 |
化学名 | [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate |
分子式 | C20H22N2O3 |
分子量 | 338.4 |
溶解度 | ≥ 16.9 mg/mL in DMSO, ≥ 4.55 mg/mL in EtOH with ultrasonic and warming |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
URB597, also known as KDS-4103, is a potent and selective inhibitor of fatty-acid amide hydrolase (FAAH), an enzyme catalyzing the intracellular hydrolysis of the endocannabinoid anandamide, with values of 50% inhibition concentration IC50 of 5 nM and 3 nM in rat brain membranes and human liver microsomes respectively. Study results have shown that, through intraperitoneal (i.p.) administration, URB597 potently inhibits FAAH in rat brain with a median inhibitory dose ID50 of 0.15 mh/kg. However, URB597 fails to show significant inhibition against a few other cannabinoid-related targets (such as cannabinoid receptors and anandamide transport) as well as a broad range of receptors, ion channels, transporters and enymes.
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