化学性质:
规格 | 1mg 5mg 10mg 50mg |
CAS | 177987-23-4 |
别名 | Heptadecyl Trifluoromethyl Ketone,OTK |
化学名 | 1,1,1-trifluoro-10Z-nonadecen-2-one |
分子式 | C19H33F3O |
分子量 | 334.5 |
溶解度 | ≤25mg/ml in DMSO;25mg/ml in dimethyl formamide |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor [1][2].
Fatty acid amide hydrolase (FAAH) is a member of the serine hydrolase family of enzymes. FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs) that hydrolyzes both oleamide and anandamide as well as several other fatty acid amides [2].
Oleyl Trifluoromethyl Ketone is an analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone. Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor in both human and rat. In transfected COS-7 cells, 10 μM oleyl trifluoromethyl ketone inhibited hydrolysis of oleamide by human and rat FAAH activities by 95.7% and 94.8%, respectively [2].
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