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N-Despropyl ropinirole is an active metabolite of the dopamine D2 receptor agonist ropinirole .1 It increases extracellular acidification rates in CHO cells expressing human dopamine D2, D3, and D4 receptors (EC50s = 0.63, 0.063, and 1.23 μM, respectively). N-Despropyl ropinirole is also a potential impurity found in commercial preparations of ropinirole.2

1.Coldwell, M.C., Boyfield, I., Brown, T., et al.Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.127(7)1696-1702(1999) 2.Coufal, P., Stulik, K., Claessens, H.A., et al.Separation and quantification of ropinirole and some impurities using capillary liquid chromatographyJ. Chromatogr. B Biomed. Sci. Appl.732(2)437-444(1999)

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