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Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence. [1][2] It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds. [3][4] Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells. [3][5][6]

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