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Gap 27 is a connexin-mimetic peptide that corresponds to amino acids 204-214 of extracellular loop 2 in connexin 43.1 It reduces survival of isolated rat osteoclasts when used at a concentration of 500 μM and decreases bone resorption in rat bone slice and osteoclast co-cultures.2 Gap 27 accelerates wound closure and stratification of the corneal epithelium in isolated human corneas.3 In vivo, Gap 27 reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of arterio-venous fistula (AV-shunt) surgery-induced high-output heart failure.4

1.Wright, C.S., Pollok, S., Flint, D.J., et al.The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitroJ. Cell. Physiol.227(1)77-87(2012) 2.Ilvesaro, J., Tavi, P., and Tuukkanen, J.Connexin-mimetic peptide Gap 27 decreases osteoclastic activityBMC Musculoskelet. Disord.210(2001) 3.Elbadawy, H.M., Mirabelli, P., Xeroudaki, M., et al.Effect of connexin 43 inhibition by the mimetic peptide Gap27 on corneal wound healing, inflammation and neovascularizationBr. J. Pharmacol.173(19)2880-2893(2016) 4.Lucero, C.M., Andrade, D.C., Toledo, C., et al.Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure ratsSci. Rep.10(1)6878(2020)

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