上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 5mg 10mg 25mg |
| CAS | 5 |
| 别名 | AV 411,KC-404 |
| 化学名 | 2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone |
| 分子式 | C14H18N2O |
| 分子量 | 230.3 |
| 溶解度 | ≤25mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
IC50: 54-239 nM
Ibudilast is an inhibitor of PDE4.
Phosphodiesterases (PDEs) are critical inflammation and wound healing modulators. Specific targeting of PDEs for the treatment of various diseases, such as chronic obstructive pulmonary disease (COPD), has been investigated.
In vitro: Ibudilast could potently inhibit purified human PDE4A, 4B, 4C and 4D with IC50 values at 54, 65, 239 and 166 nM, respectively. Ibudilast was also able to effectively block LPS-induced tumor necrosis factor and N-formyl-MetLeu-Phe-induced leukotriene B4 biosynthesis in human whole blood [1].
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
标签：Ibudilast
联系人：高小姐
手 机：13585831301
Q Q：3004967995
座 机：021-59541103
传 真：021-60443211
地 址：上海嘉定区嘉罗公路1661
