化学性质:
规格 | 10 mg 50 mg |
CAS | 675848-25-6 |
别名 | N/A |
化学名 | N/A |
分子式 | C12H10N2O8V |
分子量 | 361.16 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.
Rosivatz et al (2006) A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 1 780 PMID:17240976 |Sharma et al (2015) The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 1 e1500845 PMID:26601142
特别提醒:
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2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:VO-OHpic
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