L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine)CS-01Y68360

产品详情

一、概述：

化学性质：

规格	10mM*1mLinWater 50mg
CAS	83730-53-4
别名	L-BSO
化学名	N/A
分子式	C8H18N2O3S
分子量	222.31
溶解度	H2O : 41.67 mg/mL (187.44 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

L-Buthionine-(S,R)-sulfoximine (BSO: 50 μM) treatment for 48 hr results in a 95% decrease in ZAZ and M14 melanoma cell line GSH levels, and a 60% decrease in GST enzyme activity. GST-π protein and mRNA levels are significantly reduced in both cell lines[1]. L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH)[2].

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：L-Buthionine-(S R)-sulfoximine (L-Butionine sulfoximine)

热卖产品最新促销最新推荐

抑制剂 > 新陈代谢类 > L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine)

产品简介

产品详情

一、概述：

联系我们