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Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. fruticosa. It binds to PPARα and PPARβ/δ with Ki values of 2.6 and 1.7 μM, respectively. In insulin-resistant mice, 100 mg/kg/day amorfrutin B is reported to improve insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment

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