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Butenafine-13C-d3 is intended for use as an internal standard for the quantification of butenafine by GC- or LC-MS. Butenafine is a benzylamine antifungal agent that has broad-spectrum activity against 87 strains of dermatophytes (MICs = 0.0015-0.05 μg/ml), 15 strains of Aspergillus (MICs = 0.025-0.78 μg/ml), 4 strains of Cryptococcus (MICs = 0.78-1.56 μg/ml), and 67 strains of Candida (MICs = 3.13 to >100 μg/ml).1 It acts by inhibiting squalene epoxidase.2 Butenafine (50 μM) inhibits the synthesis of ergosterol , a sterol in the cell membranes of fungi. Formulations containing butenafine have been used in the treatment of tinea pedis, tinea corporis, and tinea cruris.

in patients with heparin-induced thrombocytopenia.

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