化学性质:
规格 | 25 g 50 g 100 g 250 g |
CAS | 67-43-6 |
别名 | N/A |
化学名 | N/A |
分子式 | C14H23N3O10 |
分子量 | 393.4 |
溶解度 | Ethanol: slightly soluble,Methanol: slightly soluble,PBS (pH 7.2): slightly soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
DTPA is a cell-impermeable metal chelating agent.1,2 It chelates copper, iron, zinc, and manganese, as well as calcium, magnesium, and plutonium.1,3 DTPA has been used as a metal chelating agent in the study of ferroptosis.4 It reduces the skeletal plutonium burden and incidence of bone tumors, as well as increases survival in a mouse model of intravenous plutonium exposure when administered at a dose of 500 mg/kg.3 Formulations containing DTPA conjugated to radioactive compounds have been used as diagnostic agents for brain imaging, renal visualization, and lung imaging.
1.Arts, J., Bade, S., Badrinas, M., et al.Should DTPA, an Aminocarboxylic acid (ethylenediamine-based) chelating agent, be considered a developmental toxicant•Regul. Toxicol. Pharmacol.97197-208(2018) 2.Killilea, D.W., Atamna, H., Liao, C., et al.Iron accumulation during cellular senescence in human fibroblasts in vitroAntioxid. Redox Signal.5(5)507-516(2003) 3.Osenthal, M.W., and Lindenbaum, A.Influence of DTPA therapy on long-term effects of retained monomeric plutonium: Comparison with polymeric plutoniumRadiat. Res.31(3)506-521(1967) 4.Wenzel, S.E., Tyurina, Y.Y., Zhao, J., et al.PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signalsCell171(3)628-641(2017)
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:DTPA
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