化学性质:
规格 | 10mM*1mL in DMSO 5mg 10mg 50mg 100mg |
CAS | 1155877-97-6 |
别名 | N/A |
化学名 | N/A |
分子式 | C21H19ClN2O2 |
分子量 | 366.84 |
溶解度 | DMSO : 150 mg/mL (408.90 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
D159687 is a selective PDE4D inhibitor[1]. PDE4D[1]
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1].D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line)
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: Female Cynomolgus macaques (4-6 year old) [2]
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2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:D159687
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