BI-2545CS-01Y68058_上海莼试生物技术有限公司

产品详情

一、概述：

化学性质：

规格	5mg 10mg 25mg 50mg 100mg
CAS	2162961-71-7
别名	N/A
化学名	N/A
分子式	C23H19F6N5O3
分子量	527.42
溶解度	DMSO: 250 mg/mL (474.01 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively[1].

BI-2545 displays good potency in the LPA and rat whole blood assay with IC50s of 29 nM and 96 nM, respectively[1].

BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs[1].BI-2545 (10 mg/kg; p.o.) has a half-life of t1/2=3.4 hours[1]. Animal Model: Rat[1]

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：BI-2545

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