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CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio.1 It is active against P. falciparum when used at concentrations of 10 and 100 µM.2 CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid , or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively.3 It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells (EC50s = 13 and 9.5 µM, respectively).4 CP21 (200 mg/kg) increases the excretion of iron, but not copper, zinc, calcium, or magnesium, in rabbits.5

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