上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 5mg 10mg 50mg 100mg |
| CAS | 376640-41-4 |
| 别名 | N/A |
| 化学名 | 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide |
| 分子式 | C17H21ClN4O3S2 |
| 分子量 | 428.96 |
| 溶解度 | ≥ 42.9mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
Ki: 1 μM using 11-dehydrocorticosterone as substrate
BVT 2733 is a novel, small molecule, non-steroidal, and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
11β-HSD1 has been reported to alter glucocorticoid hormone action in target tissues for insulin action and is suggested to play a key role in glucose homeostasis.
In vitro: BVT 2733 was identified as a novel type 1 selective inhibitor of murine 11β-HSD1 (Ki 1 μmol/l), which did not inhibit mouse 11β-HSD type 2 at a concentration as high as 200 μmol/l (corresponding to a Ki >33 μmol/l). Therefore, the selectivity of BVT 2733 for the 11β-HSD type 1 enzyme over the type 2 enzyme was estimated to be at least 30-fold based on the Ki values [1].
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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