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抑制剂 > 新陈代谢类 > AUTEN-99
产品名称:
AUTEN-99
型号:
CS-01Y67977
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1 mg 5 mg 10 mg 25 mg

CAS

1049780-58-6

别名

N/A

化学名

N/A

分子式

C17H14N2S.HBr

分子量

359.3

溶解度

DMSO: soluble

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

AUTEN-99 is an inhibitor of the phosphatase myotubularin-related protein 14 (MTMR14/Jumpy).1 It inhibits MTMR14/Jumpy activity in a cell-free assay when used at concentrations of 10 and 100 μM. AUTEN-99 (1 and 10 μM) enhances autophagic flux and increases the levels of LC3B-11 in HeLa cells. It increases survival of mouse primary neurons exposed to hydrogen peroxide as a model of oxidative stress when used at concentrations ranging from 0.5 to 5 μM. AUTEN-99 increases the number of autophagic structures in mouse pancreas, kidney, and liver following oral or intraperitoneal administration. It also induces autophagy in the Drosophila larval fat body and increases the percentage of flies climbing a glass column in a climbing assay in a transgenic model of Parkinson's disease.

1.Kovács, T., Billes, V., Komlós, M., et al.The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptomsSci. Rep.742014(2017)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:AUTEN-99 

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