化学性质:
规格 | 1mg 5mg 10mg |
CAS | 20 |
别名 | Dibromo-dodecenyl-methylsulfimide |
化学名 | 12,12-dibromo-N-(methylsulfonyl)-11-dodecenamide |
分子式 | C13H23Br2NO3S |
分子量 | 433.2 |
溶解度 | ≤20mg/ml in DMSO;30mg/ml in dimethyl formamide |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
DDMS is a CYP4A2 enzyme inhibitor.
Biosynthesis of 20-HETE from arachidonic acid by the cytochrome P450 4A (CYP450 4A) isoforms is a key component of vascular homeostasis, especially in renal circulation.
In vitro: To determine whether inhibition of 20-HETE contributes to the vasodilatory effects of NO, the effects of DDMS on the response to SNP were examined in rat renal arterioles preconstricted with phenylephrine). Results showed that after DDMS treatment, SNP could increase vascular diameter by only 17% [1].
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标签:DDMS
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