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Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.[1][2] It inhibits Src kinase with an IC50 value of 20 nM.[3]  Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. [1] It is an agonist of the farnesoid X receptor (FXR; EC50 = 3.2 μM) that reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity when administered at 30 mg/kg per day. Altenusin also has antioxidant and antifungal properties.

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