化学性质:
规格 | 5 mg 10 mg 25 mg |
CAS | 2276-93-9 |
别名 | AILCA |
化学名 | (5α)-3β-hydroxy-cholan-24-oic acid |
分子式 | C24H40O3 |
分子量 | 376.6 |
溶解度 | DMF: 1mg/mL,DMF:PBS (pH 7.2) (1:3): 0.25mg/mL |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.[1],[2] It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).[1] AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.[2]
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