4-oxo IsotretinoinCS-01Y67813_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	5 mg 10 mg 25 mg
CAS	71748-58-8
别名	N/A
化学名	N/A
分子式	C20H26O3
分子量	314.4
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 15 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

4-oxo Isotretinoin is an active metabolite of the retinoid isotretinoin .1 It is formed from isotretinoin by several cytochrome P450 (CYP450) isoforms, including CYP3A, CYP2B6, and CYP2C19.2 4-oxo Isotretinoin (10 μM) increases protein expression of cytokeratin 7 (CK7) and CK19 in normal human epidermal keratinocytes.3 It inhibits proliferation of retinoid-sensitive UM-SCC-22A and UM-SCC-35 head and neck squamous cell carcinoma (HNSCC) cells in a concentration-dependent manner.4 4-oxo Isotretinoin has been found in influent and effluent wastewater.5 It is teratogenic to mouse embryos when administered to pregnant dams at a dose of 100 mg/kg on day 11 of gestation.6

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标签：4-oxo Isotretinoin

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