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2-Chloroadenine is a heterocyclic building block that has been used in the synthesis of adenosine antimetabolites with antineoplastic activity.1 It is also the major catabolite of 2-chloro-2'-deoxyadenosine.2

1.Bauta, W.E., Schulmeier, B.E., Burke, B.J., et al.A new process for antineoplastic agent clofarabineOrg. Proc. Res. Dev.8(6)889-896(2004) 2.Bontemps, F., Delacauw, A., Cardoen, S., et al.Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-29-deoxyadenosineBiochem. Pharmacol.59(10)1237-1243(2000)

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