化学性质:
规格 | 10mM*1mLinDMSO 100mg 500mg |
CAS | 15727-65-8 |
别名 | N/A |
化学名 | N/A |
分子式 | C12H8 |
分子量 | 152.19 |
溶解度 | DMSO : ≥ 125 mg/mL (821.34 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.
1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1].
[1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.
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