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Benzenesulfonamide, the amide of benzenesulfonic acid, has been used to produce various derivatives, especially those used as intermediates in the synthesis of photochemicals, dyes, disinfectants, as well as pharmaceuticals.

In vitro: In a previous study, a series of N-aryl-β-alanine- and diazo-derivatives of benzenesulfonamide were designed, synthesized, and their binding affinities to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was investigated by the use of isothermal titration calorimetry and fluorescent thermal shift assay. The results indicated that 4-substituted diazobenzenesulfonamides were found to be most potent CA binders among the synthesized derivatives. In addition, the majority of the N-aryl-β-alanine derivatives had better affinity for CA II while diazobenzenesulfonamides showed nanomolar affinities towards CA I isozyme. Moreover, the X-ray crystallographic data showed the binding modes of both derivative groups [1].

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