化学性质:
规格 | 5 mg 25 mg |
CAS | 393121-74-9 |
别名 | N/A |
化学名 | N/A |
分子式 | C16H17NO2 |
分子量 | 255.31 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).
Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID:27435961
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