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3,8’-Biapigenin is a polyketide synthase-derived biflavonoid that has been found in Hypericum and has diverse biological activities.1,2,3,4,5 It inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 4.5 μM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 μM.2 3,8’-Biapigenin inhibits the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, and CYP1A2 (Kis = 0.038, 0.32, and 0.95 μM, respectively).3 It reverses cell death induced by kainate and NMDA in isolated rat embryonic hippocampal neurons when used at a concentration of 10 μM.4 3,8’-Biapigenin (8 mg/kg) decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats.5

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