化学性质:
规格 | 1mg |
CAS | 1246816-93-2 |
别名 | N/A |
化学名 | N/A |
分子式 | C14H7D4NO5 |
分子量 | 277.3 |
溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Tolcapone-d4 is intended for use as an internal standard for the quantification of tolcapone by GC- or LC-MS. Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA .1,2 Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.3,4 By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson's disease.3
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:Tolcapone-d4
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