化学性质:
规格 | 5mg 10mg 50mg 100mg |
CAS | 1314891-22-9 |
别名 | N/A |
化学名 | N/A |
分子式 | C23H19F3N4O3 |
分子量 | 456.42 |
溶解度 | DMSO : ≥ 100 mg/mL (219.10 mM);H2O : < 0.1 mg/mL (insoluble) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM.
TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures. TMP195 significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle group. In the transcriptional profiling data from the PHA-stimulated PBMC experiments, CCL2 and CCL1 are respectively down- or upregulated by TMP195[1]. TMP195 occupies the acetyllysine-binding site of class IIa HDACs. TMP195 competes against binding of HDAC7 to a variety of side-chain modifications on the same peptide backbone, despite no interference with the activity of other acetyllysine reader proteins BRD4 (IC50>50 uM)[2].
特别提醒:
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标签:TMP195
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