化学性质:
规格 | 1mg 5mg 10mg 25mg |
CAS | 420092-79-1 |
别名 | N/A |
化学名 | 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide |
分子式 | C16H11ClN2O5S |
分子量 | 378.8 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.16 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.
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