化学性质:
规格 | 10mM (in 1mL DMSO) 10mg 50mg |
CAS | 537672-41-6 |
别名 |
|
化学名 | 4-bromo-N'-butylbenzohydrazide |
分子式 | C11H15BrN2O |
分子量 | 271.15 |
溶解度 | ≥ 10.65mg/mL in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
UF 010 is a novel and selective class I HDAC inhibitor with IC50 values of 0.5, 0.1, 0.06, 1.5, 9.1, 15.3 and 44.5 μM for HDAC1, 2, 3, 8, 6, 10 and 11 [1].
Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from ε-N-acetyl lysines on histones, allowing the histones to wrap the DNA more tightly. DNA expression is regulated by de-acetylation and acetylation.
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