化学性质：                                                                                                             

产品描述：                                                                                                            

Tubacin is a potent, selective, reversible, and cell-permeable inhibitor of HDAC6 with an IC50 value of 4 nM.[1]

Histone deacetylases (HDACs) can be divided into 4 classes, among whom Class I, II, and IV is nuclear zinc-dependent enzymes and Class III is nicotinamide adenine dinucleotide (NAD+) dependent. HDACs catalyze deacetylation of N-acetyl-lysine residues and play an important role in a number of biological reactions including gene expression and cell cycle. By inhibiting α-tubulindeacetylation in mammalian cells, tubacin can suppress the expression of certain genes and therefore result in an antitumor effect without the level of histone acetylation. As selective inhibitors of HDAC6 are used in the treatment of protein degradation disorders, tubacin may have therapeutic applications as antimetastatic and antiangiogenic agent.[1,2]

特别提醒：