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抑制剂 > 染色质 > TMP269
产品名称:
TMP269
型号:
CS-01Y67563
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

10mM (in 1mL DMSO) 5mg 10mg

CAS

1314890-29-3

别名

TMP 269;TMP-269

化学名

(Z)-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzimidic acid

分子式

C25H21F3N4O3S

分子量

514.52

溶解度

23mg/mL in DMSO

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

TMP269 is a novel and selective inhibitor of class IIa histone deacetylase with IC50 values of 126, 80, 36, 9 nM for HDAC 4, 5, 7, 9, respectively [1].

Histone deacetylases (HADC) are a series of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone and make the histones to wrap the DNA more tightly, which prevent transcription.

TMP269 is a novel and selective class IIa HDAC inhibitor. In MM cell lines, TMP269 induced modest cytotoxicity with IC50 values ranging from 22 to 38 μM in a dose-dependent way, which was associated with cleavage of caspase-3, -8, -9 and PARP. Also, TMP269 enhanced CFZ-induced apoptosis and increased the expression of activating transcription factor 4 (ATF4) and proapoptotic transcription factor C/EBP homologous protein (CHOP). In the presence of BMSCs or IL-6, TMP269 and CFZ also showed significant cytotoxicity [2]. In IEC-18 intestinal epithelial cells, TMP269 inhibited cell proliferation, cell cycle progression and DNA synthesis in response to G protein-coupled receptor/protein kinase D1 (PKD1) activation [3].

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:TMP269 

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