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Suberohydroxamic Acid (Suberoyl bis-hydroxamic acid, SBHA) is an inhibitor of HDAC with ID50 values of 0.25 and 0.30 μM for HDAC1 and HDAC3, respectively [1].

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from ε-N-acetyl lysines on histones, allowing the histones to wrap the DNA more tightly. DNA expression is regulated by de-acetylation and acetylation.

Suberohydroxamic Acid (SBHA) is an HDAC inhibitor. In MEL cells, SBHA induced the accumulation of acetylated H4 [1]. In medullary thyroid carcinoma (MTC) cells, SBHA dose-dependently induced the Notch-1 intracellular domain (the active form of Notch-1), which then decreased NE tumor marker chromogranin A (CgA) and achaete-scute complex-like 1 (ASCL-1), a downstream target of Notch-1 signaling. Also, SBHA increased the levels of cleaved poly ADP-ribose polymerase (PARP) and caspase-3, induced apoptosis and reduced cell viability in a dose-dependent way [2]. In MCF-7 breast cancer cells, SBHA induced the expressions of p53, p21, Bax, and PUMA, and ΔΨm collapsed, which then induced apoptosis [3]. In acute T lymphoblastic leukemia (T-ALL) cells, SBHA enhanced WNT/β-catenin signaling, blocked G2/M cell cycle progression, increased p21(WAF1) expression and inhibited cell growth. SBHA also increased the levels of cleaved PARP, caspase-9 and caspase-3, and induced apoptosis [4].

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