化学性质:
规格 | 100mg 250mg |
CAS | 4548-34-9 |
别名 |
|
化学名 | (1S,2R)-2-phenylcyclopropan-1-amine;hydrochloride |
分子式 | C9H11N.HCl |
分子量 | 169.65 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Tranylcypromine, also known as 2-PCPA, is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits MAO A and MAO B with the inhibition constant Ki values of 101.9 μM and 16 μM and the half maximal inhibition concentration IC50 values of 2.3 μM and 0.95 μM respectively [1].
Tranylcypromine has also been found to potently and irreversibly inhibit histone demethylase lysine-specific demethylase 1 (LSD1), which is an amine oxidase homologue of MAO sharing similarities in the catalytic site with MAO A and B, in a time dependent and mechanism based manner with Ki and IC50 values of 242 μM and 20.7 μM respectively [1].
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