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RN 1 dihydrochloride is a potent and selective inhibitor of LSD1 with IC50 value of 70 nM [1].

Lysine (K) -specific demethylase 1A (LSD1) is a flavin-dependent histone demethylase that demethylates mono- and di-methylated lysines and plays an important role in oocyte growth, embryogenesis and tissue-specific differentiation. LSD1 plays a role in acute myeloid leukemia (AML).

RN 1 dihydrochloride is a potent and selective LSD1 inhibitor. RN-1 inhibited monoamine oxidase MAO A and MAO B with IC50 values of 0.51 and 2.79 μM, respectively [1]. In baboon erythroid progenitor cells, RN-1 increased γ-globin expression [2].

In mice, RN-1 significantly impairs long-term memory but didn’t affect short-term memory [1]. In sickle cell disease (SCD) mice, RN-1 induced the expression of γ-globin and increased amounts of F cells and F reticulocytes [2]. In SCD mouse model, RN-1 induced HbF synthesis and increased amounts of mature erythrocytes and HbF-positive cells. Also, RN-1 reduced sickle cells and reticulocytes in the peripheral blood [3].

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