化学性质:
规格 | 1mg |
CAS |
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别名 |
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化学名 | (1Z,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S,19Z,21S)-1-((S)-1-((2S,3Z,5S,6Z,8R,9Z,12Z,14S,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,32S,33Z,35S,36Z,39Z,42Z)-44-amino-2,5-bis(4-aminobutyl)-14,17,20,23,26,29,32,35-octakis(3-guanidinopropyl)-4,7,10,13,16,19,22 |
分子式 | C111H211N59O26S |
分子量 | 2820.31 |
溶解度 | Soluble to 2 mg/ml in 20% acetonitrile / H2O |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.
特别提醒:
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标签:R8-T198wt
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