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抑制剂 > 染色质 > Remodelin
产品名称:
Remodelin
型号:
CS-01Y66927
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

5mg  25mg 100mg

CAS

1622921-15-6

别名

N/A

化学名

4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;hydrobromide

分子式

C15H15BrN4S

分子量

363.28

溶解度

36.3mg/mL in DMSO

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                             

Remodelin is a potent inhibitor of NAT10 [1].

N-acetyltransferase 10 (NAT10) is the only identified lysine acetyltransferase that acts on microtubules and histones [1]. NAT10 mainly exists in the nucleolus.

Remodelin is a potent NAT10 inhibitor. In lamin A/C depletion (siLMNA) cells, remodelin remodeled nuclear architecture through inhibition of NAT10 lysine acetyltransferase activity. In cells derived from LMNA-mutated HGPS patients and primary MRC5 fibroblasts aged in culture, Remodelin significantly decreased the prevalence of misshapen nuclei. In U2OS cells and normal fibroblasts, remodelin inhibited nuclear shape defects induced by farnesyltransferase inhibitors (FTI). In HGPS cells, remodelin reduced the amount of misshapen nuclei, suggesting that inhibition of NAT10 mediated nuclear shape normalization. Also, remodelin reduced DNA damage signaling, reduced SUN1 accumulation at the nuclear envelope, reduced the levels of autophosphorylated ATM and DNA double-strand break markers γH2AX, and improved chromatin and nucleolar organization. In siLMNA and HGPS cells, remodelin inhibited microtubule anchorage to centrosomes [1].

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:5mg  10mg 50mg 

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