化学性质:
规格 | 100mg 250mg 500mg |
CAS | 108181-00-6 |
别名 | N/A |
化学名 | N/A |
分子式 | C28H22NO2+ |
分子量 | 404.48 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1]. IC50: 1.8 μM (CARM1)[1]
DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: HELA, K562, MCF7 cells
[1]. Ye F, et al. Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. Biomed Res Int. 2016;2016:7086390.
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:DC_C66
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