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Sesquicillin A is a fungal metabolite that has been found in Albophoma.1 It inhibits the growth of A. salina brine shrimp (MIC = 6.25 μg/ml). Sesquicillin is cytotoxic to Jurkat cells (IC50 = 34 μM). It induces cell cycle arrest at the G1 phase and inhibits proliferation of MCF-7 breast cancer cells when used at a concentration of 20 μg/ml.2

1.Uchida, R., Imasato, R., Yamaguchi, Y., et al.New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778J. Antibiot. (Tokyo)58(6)397-404(2005) 2.Jeong, H.W., Lee, H.J., Kho, Y.H., et al.Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell linesBioorg. Med. Chem.10(10)3129-3134(2002)

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