化学性质:
规格 | 5mg 10mg 25mg |
CAS | 6833-84-7 |
别名 | N/A |
化学名 | (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone |
分子式 | C40H64O12 |
分子量 | 736.94 |
溶解度 | 1mg/mL in ethanol, 0.25mg/mL in DMSO, 10mg/mL in DMF |
储存条件 | Desiccate at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.[1] This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin, and dinactin that all act as ionophores for monovalent cations.[2],[3],[4],[5],[6],[7] Nonactin is a mitochondrial membrane uncoupler and an inhibitor of adenine nucleotide translocase (ANT; IC50s = 4.4, 3.3, 4.7, and 3.3 μM for recombinant human ANT1-4, respectively).[8],[9] It selectively induces apoptosis in cancer cells and induces tumor regression in mouse xenograft models expressing mutant β-catenin over cancer cells and xenografts expressing wild-type β-catenin.8 Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.[10] It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.[11] Dinactin inhibits T cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.[12]
特别提醒:
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标签:Nonactin
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