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Piliformic acid is a fungal metabolite that has been found in N. pseudotrichia and has diverse biological activities.1,2 It is cytotoxic to BC-1 human breast cancer cells (IC50 = 5 μg/ml).2 Piloformic acid is active against L. braziliensis amastigotes (IC50 = 78.5 μM). It is also active against the plant pathogenic fungi C. gloeosporioides (MIC = 292 μM).1

1.Elias, L.M., Fortkamp, D., Sartori, S.B., et al.The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnoseBraz. J. Microbiol.49(4)840-847(2018) 2.Cota, B.B., Tunes, L.G., Maia, D.N.B., et al.Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood)Mem. Inst. Oswaldo Cruz113(2)102-110(2018)

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