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抑制剂 > 凋亡抑制类 > Sodium 4-Phenylbutyrate-d11
产品名称:
Sodium 4-Phenylbutyrate-d11
型号:
CS-01Y66581
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

500 μg 1 mg

CAS

1392208-11-5

别名

N/A

化学名

N/A

分子式

C10D11O2.Na

分子量

197.3

溶解度

DMSO: 25 mM,Water: 100 mM

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                             

Sodium 4-Phenylbutyrate-d11 is intended for use as an internal standard for the quantification of sodium 4-phenylbutyrate by GC- or LC-MS. Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.1,2 It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.3,4 Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.

1.Stewart, G.A., Ridscale, R., Martin, E.P., et al.4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-CAmerican Journal of Respiration, Cell, and Molecular Biology47(3)324-331(2012) 2.Bradbury, N.A.Focus on "sodium 4-phenylbutyrate downregulates Hsc70: Implications for intracellular trafficking of δF508-CFTR"Am. J. Physiol. Cell Physiol.278(2)C257-C258(2000) 3.Lu, Q., Wang, D.S., Chen, C.S., et al.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitorsJ. Med. Chem.48(17)5530-5535(2005) 4.Ammerpohl, O., Trauzold, A., Schniewind, B., et al.Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cellsBr. J. Cancer96(1)73-81(2007)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Sodium 4-Phenylbutyrate-d11 

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