化学性质:
规格 | 10mM (in 1mL DMSO) 10mg 25mg |
CAS | 312917-14-9 |
别名 |
|
化学名 | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide |
分子式 | C20H16N2OS |
分子量 | 332.42 |
溶解度 | ≥ 16.6mg/mL in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 with pIC50 values of 6.7 and 7.5, respectively [1].
c-Jun N-terminal kinases (JNK) belong to the mitogen-activated protein kinase (MAPK) family. JNK1 and JNK2 are widely expressed, whereas JNK3 is mainly expressed in the brain and plays an important role to mediate neurodegeneration such as Alzheimer’s Disease and Parkinson’s Disease [1].
TCS JNK 5a is a selective JNK2 and JNK3 inhibitor. TCS JNK 5a exhibited selective against JNK1 and p38α with pIC50 values of 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α, respectively. Also, TCS JNK 5a was inactive at EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0 [1].
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