上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 10 mM * 1 mL in DMSO 2mg 5mg 10mg 50mg |
| CAS | 1431866-33-9 |
| 别名 | WEHI539,WEHI 539 |
| 化学名 | 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid |
| 分子式 | C31H29N5O3S2 |
| 分子量 | 583.72 |
| 溶解度 | <1.17 mg/mL in DMSO, <2.44 mg/mL in EtOH, <2.24 mg/mL in H2O |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
WEHI-539 is a small-molecule inhibitor of BCL-XLwith an IC50 value of 1.1 nM [1].
WEHI-539 was designed as a BCL-XLinhibitor with high affinity. It interacted the with the binding groove of BCL-XLwith a Kd value of 0.6 nM. In MEF cells lacking MCL-1, WEHI-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. In BCL-XLoverexpressed MEF cells, WEHI-539 showed EC50 value of 0.48 μM. WEHI-539 also significantly induced apoptosis of the platelets purified from mice. Besides that, WEHI-539can not kill MEF cells lacking BAK because the cell death mediator BAK is regulated by BCL-XLand MCL-1. [1].
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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