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Pogostone is a pyranone that has been found in the essential oil of P. cablin, also known as patchouli oil, and has antifungal and insecticidal activities.1 It is active against a laboratory strain and clinical isolates of C. albicans (MICs = 49 and 12-97 μg/ml, respectively). It reduces fungal load in the vagina in a mouse model of fluconazole-resistant vulvovaginal candidiasis when administered at topical doses of 1, 2, and 4 mg/kg per day or oral doses of 20, 40, and 80 mg/kg per day.2 Pogostone is toxic to S. exigua and S. litura larvae with LC50 values of 545.61 and 986.88 mg/L for dietary administration and 519.48 and 1,041.42 mg/L for contact application.3 It also has antifeedant activity against third instar larvae against S. exigua and S. litura.

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