上海莼试生物技术有限公司
上海莼试生物技术有限公司
| 规格 | 100mg 250mg 500mg |
| CAS | 1416663-77-8 |
| 别名 | N/A |
| 化学名 | N/A |
| 分子式 | C24H21ClF2N4O5 |
| 分子量 | 518.9 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively[1]. IC50: ~17 nM (p53-MDM2), ~24 nM (p53-MDMX)[1]
RO-5963 (10-20 μM; 48 hours) shows much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines[1].RO-5963 (10 μM, 24 hours) effectively activats p53 and elevates p21 and MDM2 levels[1]. Apoptosis Analysis[1] Cell Line: ZR75-30, MCF7 cells
[1]. Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
标签：RO-5963
联系人：高小姐
手 机：13585831301
Q Q：3004967995
座 机：021-59541103
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