PD-1-IN-22CS-01Y66048_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	100mg 250mg 500mg
CAS	2349372-98-9
别名	N/A
化学名	N/A
分子式	C25H25N5O4
分子量	459.5
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM[1]. IC50: 92.3 nM (programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction)[1]

PD-1-IN-22 dose-dependently elevates IFN-γ secretion in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells[1].

[1]. Qin M, et al. Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2019 May 9;62(9):4703-4715.

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1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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标签：PD-1-IN-22

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抑制剂 > 凋亡抑制类 > PD-1-IN-22

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