规格 | Troglitazone |
CAS | 97322-87-7 |
别名 | Rezulin;CS-045;Noscal |
化学名 | 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
分子式 | C24H27NO5S |
分子量 | 441.54 |
溶解度 | ≥ 20.9 mg/mL in DMSO, ≥ 3.34 mg/mL in EtOH with ultrasonic and warming |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARg/a dual agonists are used in the treatment of type 2 diabetes mellitus. Troglitazone is a prototypical sarcomagenic PPARg agonist.
In vitro: Troglitazone PPARγ ligands showed potent inhibitory effect on proliferation, and could induce RCC cell apoptosis, suggesting that the PPARγ ligands have potential antitumor effects on renal carcinoma cells [1].
In vivo: Troglitazone increased EC proliferation in brown and white adipose tissue and liver in mice at sarcomagenic doses (400 and 800 mg/kg) after four weeks of treatment [2].
Clinical trial: Several clinical trials have been conducted to investigate the efficacy, safety and pharmacokinetics of troglitazone in the liposarcoma and diabtes mellitus patients [3].
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标签:Troglitazone
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