HS-1371CS-01Y65796_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mM*1mLinDMSO 5mg 10mg 25mg 50mg 100mg
CAS	2158197-70-5
别名	N/A
化学名	N/A
分子式	C24H24N4O
分子量	384.47
溶解度	DMSO : 16.67 mg/mL (43.36 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM[1].

HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines[1].HS-1371 (0.1, 1, 5, 10, 20 μM, 9 h) can block RIP3 S227 phosphorylation[1].HS-1371 (0.1, 1, 5, 10 μM, 24 h) rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death[1].|| Western Blot Analysis[1]||Cell Line:|HT-29 cells |Concentration:|0.1, 1, 5, 10, 20 μM|Incubation Time:|9 h|Result:|HS-1371 shows an inhibitory effect on S227 auto-phosphorylation of RIP3.

[1]. Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125.

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标签：HS-1371

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